Fraser J R, Cunningham A L, Mathews J D, Riglar A
University of Melbourne Department of Medicine, Royal Melbourne Hospital, Victoria, Australia.
Rheumatol Int. 1988;8(3):113-7. doi: 10.1007/BF00272432.
Immune complexes were sought in serum and synovial fluid in Ross River virus disease (epidemic polyarthritis). Multiple samples from 15 patients showing varied degrees of disease activity over a 3 month period were analysed for their content of complement components C3 and C4, and for C1q solid-phase and Raji cell binding activity. Levels of C3 and C1q binding activity were normal. C4 and Raji cell binding activity were normal except for three high levels of Raji cell binding, of which two were accompanied by low levels of C4, with normal C3 and C1q binding. Synovial fluid showed anomalous Raji cell reactivity of uncertain significance. Conglutinin solid-phase binding activity and IgG rheumatoid factor were compared in the serum of 20 patients during active disease and after recovery. The results were identical and within the normal range in both phases. One patient developed IgM rheumatoid factor in a low titre late in his illness. Although these findings do not entirely exclude a role for immune complexes formed at the onset in the circulation or tissues, it is concluded from this and other evidence that circulating complexes are not commonly responsible for the persistence of syndromes in this disease.
在罗斯河病毒病（流行性多关节炎）患者的血清和滑液中寻找免疫复合物。对15名患者在3个月期间显示出不同程度疾病活动的多个样本进行分析，检测其补体成分C3和C4的含量，以及C1q固相和拉吉细胞结合活性。C3和C1q结合活性水平正常。除了三个高水平的拉吉细胞结合外，C4和拉吉细胞结合活性正常，其中两个伴有低水平的C4，而C3和C1q结合正常。滑液显示出意义不确定的异常拉吉细胞反应性。比较了20名患者在疾病活动期和康复后血清中的胶固素固相结合活性和IgG类风湿因子。两个阶段的结果相同且均在正常范围内。一名患者在疾病后期出现低滴度的IgM类风湿因子。尽管这些发现不能完全排除在疾病初期在循环系统或组织中形成的免疫复合物的作用，但根据这些及其他证据可以得出结论，循环复合物通常不是该疾病综合征持续存在的原因。
