Sottiurai V S, Fry W J, Stanley J C
Arch Surg. 1978 Nov;113(11):1280-8. doi: 10.1001/archsurg.1978.01370230070008.
Ultrastructural characteristics of 20 dysplastic human renal arteries were documented. Loss of smooth muscle with collection of fibrous connective tissue predominated in medical fibrodysplasia, whereas excessive accumulations of elastic fibrils typified perimedial dysplasia. Myofibroblasts were a unique feature of both forms of arterial dysplasia. These modified smooth muscle cells seemed to be the source of abnormal connective tissue synthesis. Transformation of medial smooth muscle cells to myofibroblasts represented a morphologic continuum. Intramedial vasa vasorum were often isolated from surrounding cellular elements by unusual amounts of mural ground substances. The results of this study lend further support to the hypothesis that ischemia and direct physical forces effect hormonally altered cells in the pathogenesis of arterial dysplasia.
记录了20条发育异常的人肾动脉的超微结构特征。在医源性纤维发育异常中，平滑肌丧失并伴有纤维结缔组织聚集占主导，而中膜周围发育异常的典型特征是弹性纤维过度积聚。肌成纤维细胞是两种动脉发育异常形式的独特特征。这些经过修饰的平滑肌细胞似乎是异常结缔组织合成的来源。中膜平滑肌细胞向肌成纤维细胞的转化代表了一种形态学上的连续过程。中膜内血管常常被异常大量的壁内基质与周围细胞成分隔离开来。本研究结果进一步支持了以下假说：在动脉发育异常的发病机制中，缺血和直接的物理力作用于激素改变的细胞。
