Christensen A, Bousfield R, Christiansen J
Department of Surgery D, Glostrup Hospital, University of Copenhagen, Denmark.
Ann Surg. 1988 Jan;207(1):4-6. doi: 10.1097/00000658-198801000-00002.
The incidence of perforated and bleeding peptic ulcer requiring emergency surgery was studied in a defined population before and after the introduction of histamine H2-blockers. The incidence of these ulcer complications was unchanged from 1974 to 1984 with an incidence of ulcer perforation from 4 to 10/100,000 per year and of bleeding ulcer from 5 to 10/100,000, indicating that the H2-blockers have not changed the incidence of severe ulcer complications.
在引入组胺H2受体阻滞剂前后,对特定人群中需要紧急手术的穿孔性和出血性消化性溃疡的发病率进行了研究。从1974年到1984年,这些溃疡并发症的发病率没有变化,溃疡穿孔的发病率为每年4至10/10万,出血性溃疡的发病率为每年5至10/10万,这表明H2受体阻滞剂并未改变严重溃疡并发症的发病率。