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H2受体拮抗剂应用前后消化性溃疡穿孔和出血的发生率

Incidence of perforated and bleeding peptic ulcers before and after the introduction of H2-receptor antagonists.

作者信息

Christensen A, Bousfield R, Christiansen J

机构信息

Department of Surgery D, Glostrup Hospital, University of Copenhagen, Denmark.

出版信息

Ann Surg. 1988 Jan;207(1):4-6. doi: 10.1097/00000658-198801000-00002.

DOI:10.1097/00000658-198801000-00002
PMID:2892468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1493241/
Abstract

The incidence of perforated and bleeding peptic ulcer requiring emergency surgery was studied in a defined population before and after the introduction of histamine H2-blockers. The incidence of these ulcer complications was unchanged from 1974 to 1984 with an incidence of ulcer perforation from 4 to 10/100,000 per year and of bleeding ulcer from 5 to 10/100,000, indicating that the H2-blockers have not changed the incidence of severe ulcer complications.

摘要

在引入组胺H2受体阻滞剂前后，对特定人群中需要紧急手术的穿孔性和出血性消化性溃疡的发病率进行了研究。从1974年到1984年，这些溃疡并发症的发病率没有变化，溃疡穿孔的发病率为每年4至10/10万，出血性溃疡的发病率为每年5至10/10万，这表明H2受体阻滞剂并未改变严重溃疡并发症的发病率。

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本文引用的文献

1
Cimetidine and perforated peptic ulcer.西咪替丁与穿孔性消化性溃疡
Br J Surg. 1982 Jun;69(6):319-20. doi: 10.1002/bjs.1800690609.
2
[Incidence of hospitalizations and operations for ulcer disease 1970-1981].[1970 - 1981年溃疡病住院和手术发生率]
Dtsch Med Wochenschr. 1983 Jun 10;108(23):891-5. doi: 10.1055/s-2008-1069662.
3
What has happened to perforated peptic ulcer?穿孔性消化性溃疡是怎么回事？
Br J Surg. 1984 Oct;71(10):774-6. doi: 10.1002/bjs.1800711012.
4
Cost effectiveness of cimetidine.西咪替丁的成本效益
Lancet. 1982 Oct 9;2(8302):828-9. doi: 10.1016/s0140-6736(82)92725-8.
5
Surgical treatment of peptic ulcer in the United States. Trends before and after the introduction of cimetidine.美国消化性溃疡的外科治疗。西咪替丁引入前后的趋势。
Lancet. 1981 Jun 13;1(8233):1305-7. doi: 10.1016/s0140-6736(81)92471-5.
6
Bleeding gastric ulcer. Surgical and non-surgical treatment of 225 patients.出血性胃溃疡。225例患者的手术及非手术治疗
Scand J Gastroenterol. 1972;7(6):535-40. doi: 10.3109/00365527209180952.
7
Perforated gastric ulcer.胃穿孔性溃疡
Postgrad Med J. 1985 Mar;61(713):217-20. doi: 10.1136/pgmj.61.713.217.
8
Non-steroidal anti-inflammatory drugs and peptic ulcer perforation.非甾体抗炎药与消化性溃疡穿孔
Gut. 1985 Apr;26(4):359-63. doi: 10.1136/gut.26.4.359.
9
Rising frequency of ulcer perforation in elderly people in the United Kingdom.英国老年人溃疡穿孔发生率上升。
Lancet. 1986 Mar 1;1(8479):489-92. doi: 10.1016/s0140-6736(86)92940-5.
10
Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer.非甾体抗炎药与出血性消化性溃疡
Lancet. 1986 Mar 1;1(8479):462-4. doi: 10.1016/s0140-6736(86)92927-2.