Müller-Lissner S A, Sonnenberg A, Schattenmann G, Hollinger A, Siewert J R, Blum A L
Am J Physiol. 1982 Jan;242(1):G9-14. doi: 10.1152/ajpgi.1982.242.1.G9.
A two-marker technique was used to determine gastric emptying rate and postprandial duodenogastric reflux rate without transpyloric intubation. The fractional gastric emptying rate in five dogs with normal pylorus was 3.0 +/- 0.3 (SE) X 10(-2)/min. In three dogs with circular pylorectomy, it was 5.8 +/- 0.8 X 10(-2)/min (P less than 0.01). The duodenogastric reflux rates were 0.72 +/- 0.23 (SE) ml/min and 3.21 +/- 0.97 ml/min. (P less than 0.05). The percentage of the test meal that by to-and-fro movements across the pylorus was emptied more than once was 2.3 +/- 1.0 (SE) in normal dogs and 15.5 +/- 2.4 after pylorectomy (P less than 0.005). Because the higher emptying rate was accompanied by more to-and-fro movements, the amount of the meal remaining in the stomach, and thus net gastric emptying, was similar in both groups. It is concluded that pylorectomy increases both reflux rate and emptying rate. This effect on emptying can only be detected by a method that includes the measurement of to-and-fro movements across the pylorus. The pylorus thus appears to prevent postprandial duodenogastric reflux and to slow gastric emptying.
采用双标记技术，在不进行经幽门插管的情况下测定胃排空率和餐后十二指肠-胃反流率。5只幽门正常犬的胃排空分数率为3.0±0.3（标准误）×10⁻²/分钟。3只行环形幽门切除术的犬，其胃排空分数率为5.8±0.8×10⁻²/分钟（P<0.01）。十二指肠-胃反流率分别为0.72±0.23（标准误）毫升/分钟和3.21±0.97毫升/分钟（P<0.05）。正常犬经幽门来回移动排空的试验餐中不止一次排空的百分比为2.3±1.0（标准误），幽门切除术后为15.5±2.4（P<0.005）。由于较高的排空率伴随着更多的来回移动，两组胃内残留的食物量以及净胃排空量相似。得出结论，幽门切除术增加了反流率和排空率。这种对排空的影响只能通过一种包括测量经幽门来回移动的方法来检测。因此，幽门似乎可防止餐后十二指肠-胃反流并减缓胃排空。
