Burke V, Malajczuk A, Gracey M, Speed T P, Thornett M L
Aust J Exp Biol Med Sci. 1978 Jun;56(3):253-63. doi: 10.1038/icb.1978.27.
Sugar absorption is increased in rats with a bile fistula but approaches normal values with the addition of bile salt. It has therefore been suggested that bile salts have a physiological role in decreasing intestinal absorption of monosaccharides. In experiments using rats, jejunal and ileal uptake of arbutin, a glucose analogue was increased 5 days after creating a bile fistula but normal by the 10th day after operation. Bile fistula rats ate only about one third of the intake of normal rats in the first 5 days after operation. Control animals fed the same amount as the bile fistula group showed a similar increase in jejunal and ileal arbutin uptake. In both groups, on the 5th post-operative day, addition of taurocholate depressed arbutin uptake towards normal. In normal rats, taurocholate depressed arbutin uptake in the ileum but not the jejunum. These results suggest that increased monosaccharide uptake in bile fistula rats is related to semi-starvation and is not a specific effect of bile salts.
胆瘘大鼠的糖吸收增加，但添加胆盐后接近正常水平。因此，有人提出胆盐在减少肠道对单糖的吸收方面具有生理作用。在使用大鼠的实验中，胆瘘形成5天后，葡萄糖类似物熊果苷在空肠和回肠的摄取增加，但术后第10天恢复正常。胆瘘大鼠在术后前5天的进食量仅约为正常大鼠的三分之一。给予与胆瘘组相同食量的对照动物，其空肠和回肠熊果苷摄取也有类似增加。在两组中，术后第5天，添加牛磺胆酸盐可使熊果苷摄取降至正常水平。在正常大鼠中，牛磺胆酸盐可降低回肠而非空肠的熊果苷摄取。这些结果表明，胆瘘大鼠单糖摄取增加与半饥饿有关，而非胆盐的特异性作用。
