Ruggiero H A, Castellanos H, Caprissi L F, Caprissi E S
Clin Cardiol. 1982 Mar;5(3):215-8. doi: 10.1002/clc.4960050303.
The effect of heparin on blood viscosity was investigated in a group of patients with acute myocardial infarction (AMI) and preinfarction angina (PA), whose blood viscosity was elevated. Viscosity was measured with Cannon, Fenske, and Routine viscometers. Kinematic viscosity, bath and whole blood, plasma, and serum viscosity were determined as well as dependent parameters (fibrinogen, serum proteins, number of platelets, and hematocrit). All of them were found to increase, and it was significantly proved that intravenous heparin immediately decreased plasma viscosity, but has a lesser effect on serum and whole blood viscosity. A dose of 1 cc = 50 mg = 5000 IU intravenous heparin, will maintain this decrease for a month. In our four-week-study, 1 cc i.v. heparin was administered at 6-hour intervals for the first 2 weeks, and 2 cc heparin subcutaneous injections were administered at 12-hour intervals for the next 2 weeks. We found that heparin also decreased fibrinogen, hematocrit, serum alpha 2 globulin, and number of platelets. Hyperviscosity, hypercoagulability, and the increase of platelet adhesiveness arae some of the most important physiopathological alterations of AMI and PA. The decrease of blood viscosity due to heparin is one of the most important and beneficial effects of it in this pathology.
在一组急性心肌梗死（AMI）和梗死前心绞痛（PA）患者中研究了肝素对血液粘度的影响，这些患者的血液粘度升高。使用坎农粘度计、芬斯克粘度计和常规粘度计测量粘度。测定了运动粘度、浴液粘度以及全血、血浆和血清粘度以及相关参数（纤维蛋白原、血清蛋白、血小板数量和血细胞比容）。发现所有这些参数均升高，并且有显著证据表明静脉注射肝素可立即降低血浆粘度，但对血清和全血粘度的影响较小。1毫升 = 50毫克 = 5000国际单位的静脉注射肝素剂量可使这种降低维持一个月。在我们为期四周的研究中，前两周每6小时静脉注射1毫升肝素，接下来的两周每12小时皮下注射2毫升肝素。我们发现肝素还可降低纤维蛋白原、血细胞比容、血清α2球蛋白和血小板数量。高粘度、高凝性以及血小板黏附性增加是急性心肌梗死和梗死前心绞痛一些最重要的生理病理改变。肝素导致的血液粘度降低是其在这种病理状态下最重要且有益的作用之一。
