Cryer A, Jones H M
Biochem J. 1978 Aug 15;174(2):447-51. doi: 10.1042/bj1740447.
The lipoprotein lipase activity of the lung, skeletal muscle, heart muscle and brown adipose tissue of the rat was studied during the period from late foetal to adult life. The enzyme activity in all four tissues emerged substantially during the first 24th after birth. Subsequently, heart and lung enzyme activity remained relatively constant per unit wet weight of tissue. The enzyme activity present in brown adipose tissue and skeletal muscle was elevated per unit weight of tissue during suckling compared with other periods of life. Delivery of near-term foetuses stimulated the emergence of enzyme activity in all four tissues with the same time course as that evoked by normal delivery. The significance of the presence of the enzyme in the tissues and the activity changes which occurred during development are discussed in relation to possible mechanisms of control.
在从胎儿晚期到成年期的这段时间里,对大鼠的肺、骨骼肌、心肌和棕色脂肪组织的脂蛋白脂肪酶活性进行了研究。在出生后的头24小时内,所有这四种组织中的酶活性都大幅出现。随后,心脏和肺的酶活性相对于单位湿重组织保持相对恒定。与生命中的其他时期相比,棕色脂肪组织和骨骼肌中每单位组织重量的酶活性在哺乳期间有所升高。接近足月胎儿的分娩刺激了所有四种组织中酶活性的出现,其时间进程与正常分娩所引发的相同。结合可能的控制机制,讨论了该酶在组织中的存在以及发育过程中发生的活性变化的意义。