Randall C L, Burling T A, Lochry E A, Sutker P B
Drug Alcohol Depend. 1982 Feb;9(1):89-95. doi: 10.1016/0376-8716(82)90028-x.
The purpose of this study was to evaluate the effect of chronic paternal alcohol consumption on fetal growth and development in C3H mice. Male mice were pair-fed isocaloric liquid diets containing either 30%, 20%, or 0% ethanol-derived calories, or given free access to lab chow. After four weeks of treatment, all males were allowed to mate with untreated females. No differences were found between the litters of alcohol-treated males and controls in terms of the number of implantation sites, prenatal mortality, fetal weight, sex ratio, or frequency of soft tissue malformations. The results suggest that paternal alcohol consumption does not grossly alter fetal growth and development in C3H mice.
本研究的目的是评估慢性父源性酒精摄入对C3H小鼠胎儿生长发育的影响。雄性小鼠被配对喂食含有30%、20%或0%乙醇热量的等热量液体饮食，或自由采食实验室饲料。治疗四周后，所有雄性小鼠与未处理的雌性小鼠交配。在植入部位数量、产前死亡率、胎儿体重、性别比例或软组织畸形频率方面，酒精处理雄性小鼠的窝仔与对照组之间未发现差异。结果表明，父源性酒精摄入不会显著改变C3H小鼠的胎儿生长发育。
