Brown M P, Stover S M, Kelly R H, Farver T B, Knight H D
J Vet Pharmacol Ther. 1981 Mar;4(1):7-10. doi: 10.1111/j.1365-2885.1981.tb00703.x.
Six adult mares were given a single intravenous injection of oxytetracycline HCl (50 mg/ml) at a dosage of 5 mg/kg. Serum, synovial fluid, peritoneal fluid, and urine oxytetracycline concentrations were measured serially over a 48-h period. The highest measured serum oxytetracycline concentration was 8.01 mcg/ml at 1/2 h. Oxytetracycline was detected in synovial fluid and peritoneal fluid, which obtained mean peak oxytetracycline concentrations of 4.43 mcg/ml and 4.20 mcg/ml, at 1/2 h and 1 h, respectively. These concentrations steadily declined in parallel with serum concentrations and were not measurable at 48 h. Urine oxytetracycline concentration was relatively high, with a peak concentration of 1565.2 mcg/ml at 1/2 h after drug administration.
给6匹成年母马静脉注射一次盐酸土霉素（50毫克/毫升），剂量为5毫克/千克。在48小时内连续测量血清、滑液、腹腔液和尿液中的土霉素浓度。给药后半小时测得的血清中土霉素最高浓度为8.01微克/毫升。在滑液和腹腔液中检测到了土霉素，其平均峰值土霉素浓度分别在半小时和1小时时为4.43微克/毫升和4.20微克/毫升。这些浓度与血清浓度平行稳步下降，在48小时时无法测得。尿液中土霉素浓度相对较高，给药后半小时峰值浓度为1565.2微克/毫升。
