Laragh J H, Sealey J E, Niarchos A P, Pickering T G
Fed Proc. 1982 Jun;41(8):2415-23.
A body of evidence has been reviewed indicating that all hypertensive phenomena ranging from mild disorders to fulminant malignant hypertension can be profitably analyzed by assessing the relative contribution of two final determinants of the arterial blood pressure--the vasoconstriction and volume components. Renin-sodium profiling and the separate application of specific pharmacologic probes provide the basic tools for identifying the relative contribution of the two components. For an equal degree of hypertension, volume forms appear to exhibit better organ flow than the more vasoconstricted forms. This bidimensional analysis has provided new understanding of the pathophysiological mechanisms of the spectrum of human hypertensive diseases of practical value for the evaluation, diagnosis, and treatment of individual patients. Beyond this, the analytical scaffold identifies some key questions for future research.
已有大量证据表明，通过评估动脉血压的两个最终决定因素——血管收缩和血容量成分的相对作用，可以对从轻度紊乱到暴发性恶性高血压的所有高血压现象进行有益的分析。肾素-钠分析以及特定药理探针的单独应用为确定这两个成分的相对作用提供了基本工具。对于同等程度的高血压，血容量型似乎比血管收缩更明显的类型表现出更好的器官血流。这种二维分析为人类高血压疾病谱的病理生理机制提供了新的认识，对个体患者的评估、诊断和治疗具有实际价值。除此之外，这种分析框架还为未来的研究确定了一些关键问题。
