Wladimiroff J W, Roodenburg P J
Eur J Obstet Gynecol Reprod Biol. 1982 Mar;13(2):67-74. doi: 10.1016/0028-2243(82)90002-8.
The effect of the beta-mimetic compound clenbuterol on maternal and fetal behaviour was studied in 12 normal primigravidae between 35 and 38 wk of gestation. None of the subjects exhibited any signs of uterine activity. Following a control period of 60 min, oral intake of 100 micrograms of clenbuterol resulted in a maximum increase in maternal and fetal heart rate of 13 and 7%, respectively. Maternal systolic blood pressure showed a rise of 6%, whereas diastolic blood pressure demonstrated a drop of 8%. The percentage incidence of fetal breathing and trunk movements did not show any significant change following oral clenbuterol administration, indicating the absence of any major effect of this drug on the fetal central nervous system. Maternal blood glucose levels demonstrated a fairly constant pattern during the entire study period.
在12名妊娠35至38周的正常初产妇中，研究了β-拟交感神经化合物克仑特罗对母体和胎儿行为的影响。所有受试者均未表现出任何子宫活动迹象。在60分钟的对照期后，口服100微克克仑特罗使母体和胎儿心率分别最大增加13%和7%。母体收缩压上升6%，而舒张压下降8%。口服克仑特罗后，胎儿呼吸和躯干运动的发生率未显示任何显著变化，表明该药物对胎儿中枢神经系统没有任何重大影响。在整个研究期间，母体血糖水平呈现出相当稳定的模式。
