接受免疫抑制治疗的炎症性肠病患者的疫苗接种问题。
Vaccination issues in patients with inflammatory bowel disease receiving immunosuppression.
作者信息
Dezfoli Seper, Melmed Gil Y
机构信息
Dr. Dezfoli is a PGY-3 Resident in Internal Medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr. Melmed is the Director of Clinical Trials at the Inflammatory Bowel Disease Center at Cedars-Sinai Medical Center and an Assistant Clinical Professor of Medicine at the David Geffen School of Medicine at the University of California, Los Angeles, both in Los Angeles, California.
出版信息
Gastroenterol Hepatol (N Y). 2012 Aug;8(8):504-12.
Abstract
Treatment regimens for Crohn's disease and ulcerative colitis increase susceptibility to infections, many of which can be prevented by vaccinations. Increased awareness concerning vaccine-preventable diseases has led to several studies investigating the immunologic responses to vaccines in immunosuppressed patients with inflammatory bowel disease. This review provides an overview of the evidence-based rationale for currently accepted recommendations regarding the use of both inactivated and live vaccines in this unique population.
摘要
克罗恩病和溃疡性结肠炎的治疗方案会增加感染易感性，其中许多感染可通过接种疫苗预防。对疫苗可预防疾病认识的提高促使了多项研究，探究免疫抑制的炎症性肠病患者对疫苗的免疫反应。本综述概述了目前关于在这一特殊人群中使用灭活疫苗和活疫苗的公认建议的循证依据。
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