Bauer H W, Gropp C, Sieber A, Bohn H
Thoraxchir Vask Chir. 1977 Jun;25(3):139-45. doi: 10.1055/s-0028-1096703.
Alpha-2 pregnancy associated glycoprotein is a high molecular, carbohydrate containing plasma protein with unknown biological function. During clinical treatment of 25 patients with bronchial carcinoma alpha-2 PAG was measured by the electroimmuno-diffusion method according to Laurell. A good correlation was observed between alpha-2 PAG serum levels and the course of the disease in 21 patients. Patients whose course of disease could not be influenced therapeutically showed continously increasing levels of alpha-2 PAG; patients who responded to therapy, showed a significant decrease in alpha-2 PAG serum levels. These findings indicate that periodic determinations of serum alpha-2 PAG may be helpful for controlling the course of bronchial carcinoma.
α-2妊娠相关糖蛋白是一种高分子量、含碳水化合物的血浆蛋白，其生物学功能尚不清楚。在对25例支气管癌患者进行临床治疗期间，根据劳雷尔法用电免疫扩散法测定α-2 PAG。在21例患者中观察到α-2 PAG血清水平与病程之间有良好的相关性。疾病进程无法通过治疗得到影响的患者，其α-2 PAG水平持续升高；对治疗有反应的患者，其α-2 PAG血清水平显著下降。这些发现表明，定期测定血清α-2 PAG可能有助于控制支气管癌的病程。
