Taylor D J, Braithwaite R A
Br Heart J. 1978 Sep;40(9):1005-9. doi: 10.1136/hrt.40.9.1005.
Systolic time intervals and drug plasma concentrations have been measured in a group of patients receiving repeated treatment with nortriptyline. Significant positive correlations between plasma nortriptyline levels and prolongation of pre-ejection phase (P less than 0.005)) and increase in the ratio pre-ejection phase, left ventricular ejection time (P less than 0.05) were obtained. A deterioration in cardiac function, with increase in heart rate, resulting in a negative inotropic effect has been shown to occur with therapeutic doses of nortriptyline. The potential dangers of tricyclic antidepressant drugs on the heart in patients whose myocardium is already compromised or those who accumulate high plasma concentrations are emphasised.
已对一组接受去甲替林重复治疗的患者测量了收缩期时间间期和药物血浆浓度。血浆去甲替林水平与射血前期延长（P<0.005）以及射血前期与左心室射血时间比值增加（P<0.05）之间存在显著正相关。已表明，治疗剂量的去甲替林会导致心功能恶化，心率增加，从而产生负性肌力作用。强调了三环类抗抑郁药对心肌已受损或血浆浓度高的患者心脏的潜在危险。
