Fiore C E, Carnemolla G, Grillo S, Grimaldi D R, Petralito A
Acta Cardiol. 1978;33(3):155-66.
The Authors have studied th haemodynamic response of ten normal subjects to the intravenous administration of 160 MRC.U. of Calcitonin in 60 min, by serial measurement of the systolic time intervals. The analysis of results pointed out a minor inotropic effect starting from the 10th minute from the beginning of the infusion. Little but significant decrements (P less than 0.01) in the duration of the pre-ejection phase of the isovolumetric contraction time, as well as a significant increase (P less than 0.01) in the LVET/PEP ratio, have been noted. A negative chronotropic effect (P less than 0.05) has been noted starting from the 30th minute. The mechanism by which Calcitonin can modify the myocardial inotropism in the normal subject is till now unknown, and it could be related to the interference of this hormore on the endocellular movements of Calcium, and on the cellular levels of cyclic AMP.
作者通过连续测量收缩期时间间期，研究了10名正常受试者在60分钟内静脉注射160 MRC单位降钙素后的血流动力学反应。结果分析表明，从输注开始第10分钟起出现轻微的变力作用。已注意到等容收缩期射血前期持续时间有轻微但显著的缩短（P小于0.01），以及左室射血时间/射血前期比值显著增加（P小于0.01）。从第30分钟起出现负性变时作用（P小于0.05）。降钙素在正常受试者中改变心肌收缩性的机制目前尚不清楚，可能与该激素对钙的细胞内运动以及细胞内环磷酸腺苷水平的干扰有关。
