Urano M, Rice L C, Montoya V
Int J Radiat Oncol Biol Phys. 1982 Feb;8(2):227-33. doi: 10.1016/0360-3016(82)90518-1.
The effect of multiple hyperthermia and the kinetics of thermal resistance were studied in experimental murine tumors. A spontaneous C3Hf mouse mammary carcinoma, MCa had a chemically-induced fibrosarcoma, FAa-1, were used. Assay methods included determination of the TCD50, i.e., the treatment time to yield a tumor control in half the treated animals and TG (tumor growth) time analysis, i.e., the time required for a tumor to reach a given size after first treatment. After equal dose fractions the TCD50 of MCa increased with increasing overall treatment time. This increase was most predominant when treatments were given with a time interval of one day. Isoeffect curves for the MCa were comparable to those for normal tissue damage (foot reaction), which was reported in the first part of this series of communications. The kinetics of thermal resistance in the MCa was compared with that in FSa-I since the fractionated hyperthermia for the FSa-I was reported to have resulted in an appreciable therapeutic gain. The magnitude of thermal resistance was far greater in the MCa than in the FSa-I, although the kinetics of thermal resistance was similar in both tumors; i.e., (a) the resistance reached a maximum in 24 hours after treatment and then decayed slowly, and (b) the development of thermal resistance increased with increasing initial dose. The thermal resistance in these tumors appeared to be greater than that in animal feet.
在实验性小鼠肿瘤中研究了多次热疗的效果及热耐受动力学。使用了自发的C3Hf小鼠乳腺癌MCa以及化学诱导的纤维肉瘤FAa - 1。检测方法包括确定TCD50，即使一半接受治疗的动物肿瘤得到控制的治疗时间，以及TG（肿瘤生长）时间分析，即肿瘤在首次治疗后达到给定大小所需的时间。在给予相等剂量分割后，MCa的TCD50随总治疗时间的增加而增加。当治疗间隔为一天时，这种增加最为显著。MCa的等效效应曲线与本系列通讯第一部分中报道的正常组织损伤（足部反应）的等效效应曲线相当。将MCa中的热耐受动力学与FSa - I中的进行了比较，因为据报道FSa - I的分次热疗产生了显著的治疗增益。尽管两种肿瘤的热耐受动力学相似，即（a）治疗后24小时内耐受达到最大值，然后缓慢衰减，且（b）热耐受的发展随初始剂量的增加而增加，但MCa中的热耐受程度远大于FSa - I。这些肿瘤中的热耐受似乎大于动物足部的热耐受。
