胰脂肪酶对乳脂肪球的水解作用。辅脂酶、磷脂酶A2和胆汁盐的作用。
Hydrolysis of milk fat globules by pancreatic lipase. Role of colipase, phospholipase A2, and bile salts.
作者信息
Borgström B, Erlanson-Albertsson C
出版信息
J Clin Invest. 1982 Jul;70(1):30-2. doi: 10.1172/jci110599.
Abstract
Human milk fat globules require colipase to be hydrolyzed by pancreatic lipase in the presence of bile salts. This is contrary to a recent report in this Journal (J. Clin. Invest. 67: 1748-1752.) according to which inhibition of lipase by bile salt could be overcome by the addition of colipase or phospholipase A2. This latter finding is shown to be due to contamination of commercially available pancreatic phospholipase A2 by colipase.
摘要
人乳脂肪球需要在胆汁盐存在的情况下，借助辅脂酶才能被胰脂肪酶水解。这与《临床研究杂志》（J. Clin. Invest. 67: 1748 - 1752.）最近的一篇报道相反，该报道称添加辅脂酶或磷脂酶A2可克服胆汁盐对脂肪酶的抑制作用。后一项发现被证明是由于市售胰磷脂酶A2被辅脂酶污染所致。
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Hydrolysis of milk fat globules by pancreatic lipase. Role of colipase, phospholipase A2, and bile salts.胰脂肪酶对乳脂肪球的水解作用。辅脂酶、磷脂酶A2和胆汁盐的作用。
J Clin Invest. 1982 Jul;70(1):30-2. doi: 10.1172/jci110599.
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Hydrolysis of human milk fat globules by pancreatic lipase: role of colipase, phospholipase A2, and bile salts.胰脂肪酶对人乳脂肪球的水解作用：辅脂酶、磷脂酶A2和胆汁盐的作用
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1
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Methods Enzymol. 1981;72:319-25. doi: 10.1016/s0076-6879(81)72022-6.
2
Hydrolysis of human milk fat globules by pancreatic lipase: role of colipase, phospholipase A2, and bile salts.胰脂肪酶对人乳脂肪球的水解作用：辅脂酶、磷脂酶A2和胆汁盐的作用
J Clin Invest. 1981 Jun;67(6):1748-52. doi: 10.1172/jci110213.
3
The isolation and properties of two prephospholipases A2 from porcine pancreas.来自猪胰腺的两种前磷脂酶A2的分离与特性
Eur J Biochem. 1973 Dec 3;40(1):1-7. doi: 10.1111/j.1432-1033.1973.tb03161.x.
4
Lipase and co-lipase activities of human small intestinal contents after a liquid test meal.液体试验餐后人体小肠内容物的脂肪酶和辅脂肪酶活性。
Scand J Gastroenterol. 1975;10(6):585-91.
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Preparation of porcine pancreatic lipase free of co-lipase activity.无辅脂酶活性的猪胰脂肪酶的制备。
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