凝血因子VIII：C一期法与二期法检测结果的差异。

Discrepancy between one-stage and two-stage assay of factor VIII:C.

作者信息

Kirkwood T B, Barrowcliffe T W

出版信息

Br J Haematol. 1978 Oct;40(2):333-8. doi: 10.1111/j.1365-2141.1978.tb03668.x.

DOI:10.1111/j.1365-2141.1978.tb03668.x

Abstract

Two methods (one-stage and two-stage) are commonly used for the assay of factor VIII clotting activity (VIII:C). We present collected data from seven separate studies of VIII:C assay which show that these methods do not give the same result when comparing concentrates and plasma. On average, two-stage assays detect 20% more VIII:C activity in concentrates as compared to plasmas than do one-stage assays.

摘要

两种方法（一步法和两步法）常用于检测凝血因子VIII的凝血活性（VIII:C）。我们展示了七项关于VIII:C检测的独立研究收集的数据，这些数据表明，在比较浓缩物和血浆时，这两种方法得出的结果不同。平均而言，与一步法相比，两步法检测到的浓缩物中的VIII:C活性比血浆中的高20%。