泛酸缺乏大鼠体内的辅酶A代谢

Coenzyme A metabolism in pantothenic acid-deficient rats.

作者信息

Reibel D K, Wyse B W, Berkich D A, Neely J R

出版信息

J Nutr. 1982 Jun;112(6):1144-50. doi: 10.1093/jn/112.6.1144.

DOI:10.1093/jn/112.6.1144

Abstract

The pantothenic acid (PA) and coenzyme A (CoA) content of various organs of rats maintained on a PA-deficient diet were determined. The PA content of heart, kidney, gastrocnemius and testes of rats fed the PA-deficient diet was reduced by greater than 90%, and liver PA was reduced by 70%. However, these low PA levels were sufficient to maintain tissue CoA at control levels. Although CoA levels were maintained, the PA-deficient rats did not grow at normal rates suggesting that low PA may effect growth rate by mechanisms other than by depressed CoA. PA-deficient rats were subjected to fasting and alloxan-diabetes to determine if increased CoA synthesis occurred as in normal animals. Both fasting and diabetes resulted in elevations in myocardial and liver CoA, which were comparable in rats fed a PA-deficient diet or a regular diet. The source of the PA used for the increase in tissue CoA in PA-deficient rats has yet to be determined.

摘要

测定了食用泛酸（PA）缺乏饮食的大鼠各器官中泛酸（PA）和辅酶A（CoA）的含量。食用PA缺乏饮食的大鼠心脏、肾脏、腓肠肌和睾丸中的PA含量降低了90%以上，肝脏PA降低了70%。然而，这些低PA水平足以将组织CoA维持在对照水平。尽管CoA水平得以维持，但PA缺乏的大鼠生长速度不正常，这表明低PA可能通过除抑制CoA以外的机制影响生长速度。对PA缺乏的大鼠进行禁食和四氧嘧啶糖尿病处理，以确定是否会像正常动物那样发生CoA合成增加。禁食和糖尿病均导致心肌和肝脏CoA升高，在食用PA缺乏饮食或常规饮食的大鼠中这一情况相当。PA缺乏大鼠组织CoA增加所使用的PA来源尚未确定。