Velcek F T, Kugaczewski J T, Jongco B, Shaftan G W, Rao P S, Schiffman G, Kottmeier P K
J Trauma. 1982 Jun;22(6):502-6. doi: 10.1097/00005373-198206000-00011.
The function of replanted splenic fragments was studied by comparing three groups of five dogs each, one group with intact spleens; one, post-splenectomy; and one with splenic replantation. Fifteen fragments were implanted into the omentum. Howell-Jolly bodies appeared after splenectomy but cleared in the replanted group after several months. I125-tagged attenuated pneumococcal clearance studies showed a significant difference between control and replanted group compared with the splenectomized group. The increase of pneumococcal antibody titers after vaccination differed significantly between the splenectomized and the replanted group. All replanted fragments were viable and showed growth over a 2-year period. These studies demonstrate that omental replantation of the canine spleen leads to the maintenance of certain functional splenic parameters comparable to the normal spleen which are significantly different from the splenectomized animal.
通过比较三组实验犬（每组五只）来研究再植脾碎片的功能，一组脾脏完整；一组行脾切除术后；一组行脾再植术。将15个脾碎片植入大网膜。脾切除术后出现豪-焦小体，但再植组在几个月后消失。I125标记的减毒肺炎球菌清除率研究显示，与脾切除组相比，对照组和再植组之间存在显著差异。脾切除组和再植组接种疫苗后肺炎球菌抗体滴度的升高有显著差异。所有再植的脾碎片均存活，并在两年内生长。这些研究表明，犬脾大网膜再植可维持某些与正常脾脏相当的脾功能参数，这与脾切除动物有显著差异。
