Qasim M M
Strahlentherapie. 1977 Aug;153(8):531-2.
315 patients with bony metastasis were given palliative radiation therapy for the control of pain; 69 of these patients received single high dose treatment and the remaining patients were treated by daily fractionation. No difference in the pain relief was observed in either method of irradiation. Morbidity was slightly more with single dose therapy, but was well tolerated. Rapid relief of pain, avoidance of exhausting and painful journey for daily treatment and saving of machine time in the busy radiotherapy department make single dose therapy a preferable modality in the management of bony metastasis.
315例骨转移患者接受姑息性放射治疗以控制疼痛；其中69例患者接受单次大剂量治疗，其余患者采用每日分次治疗。两种照射方法在疼痛缓解方面均未观察到差异。单次剂量治疗的发病率略高，但耐受性良好。疼痛迅速缓解、避免每日治疗带来的疲惫和痛苦旅程以及在繁忙的放疗科节省机器时间，使得单次剂量治疗成为骨转移治疗中一种更可取的方式。
