Needham P R, Mithal N P, Hoskin P J
Department of Radiotherapy and Oncology, Royal London Hospital, UK.
J R Soc Med. 1994 Sep;87(9):503-5.
Painful bone metastases are a common problem for cancer patients. Although current evidence supports the use of a single fraction of radiotherapy as the treatment of choice, many radiotherapists, for a variety of reasons, continue to use fractionated regimens. Over one six month period 105 patients received external beam irradiation for painful bone metastases at the Royal London Hospital (RLH). Thirty-one per cent of the patients were aged 70 or over. The treatment of 97 of these patients was assessed. They had a total of 280 sites treated over the course of their disease. Fifty-nine per cent of sites treated received a fractionated course of radiotherapy. Site significantly influenced fractionation. Overall response rates of 82% were achieved. Fractionation did not appear to influence this. Ten patients received large field irradiation. Fifteen patients had five or more sites irradiated, of whom only one received hemibody irradiation.
疼痛性骨转移是癌症患者的常见问题。尽管目前的证据支持采用单次分割放疗作为首选治疗方法，但由于各种原因，许多放疗科医生仍继续使用分次放疗方案。在六个月的时间里，105名患者在皇家伦敦医院（RLH）接受了针对疼痛性骨转移的外照射治疗。其中31%的患者年龄在70岁及以上。对其中97名患者的治疗情况进行了评估。在他们的病程中，总共280个部位接受了治疗。接受治疗的部位中有59%接受了分次放疗疗程。部位对分割方式有显著影响。总体缓解率达到了82%。分割方式似乎并未对此产生影响。10名患者接受了大野照射。15名患者有五个或更多部位接受了照射，其中只有一人接受了半身照射。
