Meisenberg G, Simmons W H
Pharmacol Biochem Behav. 1982 May;16(5):819-25. doi: 10.1016/0091-3057(82)90242-8.
The neurohypophyseal hormones oxytocin and vasopressin evoke characteristic behavioral changes after intracerebroventricular injection in mice. These included the induction of excessive grooming and scratching in an unrestricted environment and of escape behavior in stressful situations. The structure-activity relations of 33 neurohypophyseal hormones and hormone analogs in the induction of these behavioral changes were examined. The results demonstrate that these effects generally parallel the vasoconstrictory effects of th peptides. It is suggested that the behavioral effects are mediated by a receptor that is closely related biochemically to the vasopressin receptors in blood vessels. They are not related to the long-term effects of neurohypophyseal hormones on learned behavior. A competitive antagonist of the short-term behavioral effects of these peptides is described. This analog also antagonizes some of the hormonal effects of vasopressin and related peptides.
神经垂体激素催产素和血管加压素在小鼠脑室内注射后会引发特定的行为变化。这些变化包括在无限制环境中过度梳理毛发和抓挠，以及在应激情况下的逃避行为。研究了33种神经垂体激素和激素类似物在引发这些行为变化方面的构效关系。结果表明，这些效应通常与这些肽的血管收缩效应平行。有人提出，行为效应是由一种在生化上与血管中的血管加压素受体密切相关的受体介导的。它们与神经垂体激素对学习行为的长期影响无关。描述了一种对这些肽的短期行为效应具有竞争性的拮抗剂。这种类似物也能拮抗血管加压素和相关肽的一些激素效应。
