Meisenberg G
Peptides. 1981 Spring;2(1):1-8. doi: 10.1016/s0196-9781(81)80003-4.
The acute behavioral effects of some neurohypophyseal hormones after intracerebroventricular injection in mice were examined. The effects, consisting mainly of a dose-dependent stimulation of certain behaviors, were demonstrated in three different behavioral tests. The type of the induced behaviors was dependent on the experimental conditions: If the mice were placed into a cage after the injection of the peptides, excessive scratching and grooming behaviors were induced. If they were exposed to stressful environmental influences, however, escape-directed activity was markedly stimulated with only minimal elevation of scratching and grooming behaviors. Very low doses down to less than 1 nanogram per mouse were effective. The effects can be observed after central, but not after peripheral application of the peptides and are mediated by a mechanism that displays some degree of specificity. An activity unit for the behavior-altering potency of the peptides was defined. A role of neurohypophyseal hormones or related peptides in the regulation of motivation and behavioral arousal is suggested.
研究了在小鼠脑室内注射某些神经垂体激素后的急性行为效应。在三种不同的行为测试中证实了这些效应，主要表现为对某些行为的剂量依赖性刺激。所诱导行为的类型取决于实验条件：如果在注射肽后将小鼠放入笼中，会诱导过度抓挠和梳理行为。然而，如果它们受到应激性环境影响，则逃避导向活动会受到明显刺激，而抓挠和梳理行为仅有轻微增加。低至每只小鼠小于1纳克的极低剂量也有效。这些效应在肽经中枢给药后可观察到，但经外周给药后则观察不到，且由一种具有一定特异性的机制介导。定义了肽改变行为效力的活性单位。提示神经垂体激素或相关肽在动机调节和行为唤醒中起作用。
