Galle P, Villiaumey J
Rev Rhum Mal Osteoartic. 1982 Mar 25;49(4):273-9.
Ultrastructural investigation of bone marrow cells of histiocytic lineage to determine the presence of microcrystals containing gold was carried out in 12 patients. Eleven patients had classical or definite rheumatoid arthritis and one had palindromic rheumatism; the duration of these diseases ranged from 6 months to 10 years. Two patients had never received chrysotherapy and therefore served as controls. The remaining 10 patients had been treated with sodium aurothiopropanolsulfonate for periods ranging from 1 week to 4 years and 4 months without any clinical signs of laboratory findings--hematological changes in particular--of drug intolerance. No crystalline structures could be found in the 2 controls or in the patient who had just begun treatment. Conversely, in the 9 other patients, the lysozymes of bone marrow macrophages contained needle-like microcrystals containing one atom of gold for two atoms of sulfur, i.e. identical in proportion to the injected product. For equivalent total doses, deposits appeared to be equally numerous regardless of the time span between the last injection and the sampling (2-21 months). These crystals were present in the bone marrow several years after the beginning of chrysotherapy. The actual mechanism of their precipitation remains unknown at present.
对12例患者的组织细胞系骨髓细胞进行超微结构研究，以确定含金黄微晶的存在情况。11例患者患有典型或明确的类风湿性关节炎，1例患有回纹型风湿症；这些疾病的病程为6个月至10年。2例患者从未接受过金疗法，因此作为对照。其余10例患者接受硫代丙醇金酸钠治疗，疗程从1周至4年4个月不等，且无任何药物不耐受的临床体征或实验室检查结果——尤其是血液学变化。在2例对照患者或刚开始治疗的患者中未发现晶体结构。相反，在其他9例患者中，骨髓巨噬细胞的溶菌酶含有针状微晶，其中金原子与硫原子的比例为1:2，即与注射产品的比例相同。对于等效的总剂量，无论最后一次注射与取样之间的时间间隔（2 - 21个月）如何，沉积物的数量似乎都相等。这些晶体在金疗法开始后的几年里一直存在于骨髓中。目前其沉淀的实际机制尚不清楚。
