Karpathios T, Antypas A, Dimitiriou P, Nicolaidou P, Fretzayas A, Thomaidis T, Matsaniotis N
Scand J Haematol. 1982 Mar;28(3):220-6. doi: 10.1111/j.1600-0609.1982.tb00518.x.
18 thalassaemic children, aged 3.5 to 13 years comprise our clinical material. In 14 of them clinically elicited spleen markings, haematocrit, blood platelet count and red cell morphology were studied daily for the whole period between transfusions. In 10 patients considerable changes in spleen size were noticed. According to out clinical observations the spleen size starts decreasing 1 to 3 d after blood transfusion up to the 10th posttransfusion day fluctuating thereafter to reach its maximum size again prior to the next blood transfusion. The decrease of spleen size was followed by an increase of haematocrit and blood platelet count and vice versa. 4 additional children were studied clinically only twice: prior to and 7 to 10 d after blood transfusion. A definite decrease of the spleen size following blood transfusion was observed. Spleen and liver 99mTc-sulfur colloid uptake was studied in 10 of the above children prior to and 7 to 10 d after blood transfusion. Statistically significant post-transfusion increase of the spleen uptake was demonstrated. Our findings suggest that (a) splenic size is relevant to blood volume sequestrated int this organ, (b) splenic radioactive uptake increases with its post-transfusion reduction in size.
我们的临床资料包括18名3.5至13岁的地中海贫血儿童。其中14名儿童在两次输血间隔期内，每天都对临床引出的脾影、血细胞比容、血小板计数和红细胞形态进行研究。10名患者的脾脏大小出现了显著变化。根据我们的临床观察，脾脏大小在输血后1至3天开始减小，直至输血后第10天，此后波动，在下一次输血前再次达到最大尺寸。脾脏大小减小后，血细胞比容和血小板计数增加，反之亦然。另外4名儿童仅在输血前和输血后7至10天进行了两次临床研究。观察到输血后脾脏大小明显减小。对上述10名儿童在输血前和输血后7至10天进行了脾脏和肝脏99mTc-硫胶体摄取研究。结果显示输血后脾脏摄取有统计学意义的增加。我们的研究结果表明：（a）脾脏大小与该器官内封存的血容量有关；（b）脾脏放射性摄取随着输血后大小的减小而增加。
