Karpathios T H, Dimitriou P, Giamouris J, Nicolaidou P, Antipas S E, Matsaniotis N
Eur J Nucl Med. 1983;8(1):15-8. doi: 10.1007/BF00263508.
Denatured radioiodinated human serum albumin (DHA) clearance studies at a dose of 1 mg/kg body wt., were carried out in 16 thalassemic children, prior to and 7-10 days following blood transfusion, to investigate changes of the effective RES blood flow which might accompany the posttransfusion spleen size diminution. A statistically significant increase (P less than 0.001) of the DHA plasma clearance rate was observed 7-10 days following blood transfusion denoting an increase of the blood flow to the effective RES while at the same time the spleen diminished in size. It is suggested that changes in the effective RES blood flow in these patients are directly related to changes in the intrasplenic circulatory capacity.
在16名地中海贫血儿童中，于输血前及输血后7 - 10天，进行了剂量为1mg/kg体重的变性放射性碘化人血清白蛋白（DHA）清除率研究，以调查输血后脾脏大小缩小可能伴随的有效网状内皮系统（RES）血流变化。输血后7 - 10天观察到DHA血浆清除率有统计学意义的显著增加（P小于0.001），这表明有效RES的血流增加，而与此同时脾脏大小缩小。提示这些患者有效RES血流的变化与脾内循环能力的变化直接相关。
