Lin H S, Kuhn C, Chen D M
Am Rev Respir Dis. 1982 Jun;125(6):712-5. doi: 10.1164/arrd.1982.125.6.712.
We investigated the effect of prolonged monocytopenia induced by daily injections of hydrocortisone acetate on the number of alveolar cells and alveolar macrophage colony-forming cells (AL-CFC) in mice. We did not observe an appreciable reduction in the number of either alveolar macrophages of AL-CFC under this experimental condition, which markedly inhibited the blood monocyte concentration over 10 days. These results suggest the existence of a mechanism by which the number of alveolar macrophages, including AL-CFC, can be maintained without a continuous migration of blood monocytes into alveolar spaces.
我们研究了每日注射醋酸氢化可的松诱导的长期单核细胞减少对小鼠肺泡细胞数量和肺泡巨噬细胞集落形成细胞（AL-CFC）的影响。在该实验条件下，我们未观察到AL-CFC的肺泡巨噬细胞数量有明显减少，此实验条件在10天内显著抑制了血液单核细胞浓度。这些结果表明存在一种机制，通过该机制，包括AL-CFC在内的肺泡巨噬细胞数量可以在没有血液单核细胞持续迁移到肺泡空间的情况下得以维持。
