Mancia G, Pomidossi G, Parati G, Bertinieri G, Grassi G, Navone F, Ferrari A, Gregorini L, Zanchetti A
Br J Clin Pharmacol. 1982 Jun;13(1 Suppl):27S-35S. doi: 10.1111/j.1365-2125.1982.tb01886.x.
1 The anti-hypertensive effect of labetalol given twice or three times daily was evaluated in ambulant subjects with essential hypertension by recording blood pressure directly for 24 h before and after 15 d of labetalol administration (daily dose 600-1800 mg). 2 Labetalol reduced 24 h systolic and diastolic blood pressures by about 20%. The reduction was evident throughout the whole 24 h period, although it was less marked during sleep. The hypotensive effect was similar when the drug was given twice or three times daily. 3 The 24 h heart rate was reduced during labetalol treatment. However, this effect was less marked than the hypotensive effect and was not present in all subjects. 4 There was a reduction in the standard deviations of blood pressure and heart rate values. However, in neither case was the coefficient of variation altered, indicating that labetalol did not have any significant effect on the shape of the 24 h blood pressure measurements.
1 通过在拉贝洛尔给药15天（日剂量600 - 1800毫克）前后直接记录24小时血压，评估了每日给药两次或三次的拉贝洛尔对原发性高血压门诊患者的降压效果。2 拉贝洛尔使24小时收缩压和舒张压降低约20%。尽管在睡眠期间降低幅度较小，但在整个24小时期间这种降低都是明显的。每日给药两次或三次时降压效果相似。3 在拉贝洛尔治疗期间，24小时心率降低。然而，这种效果不如降压效果明显，且并非所有受试者都有此现象。4 血压和心率值的标准差有所降低。然而，在这两种情况下变异系数均未改变，表明拉贝洛尔对24小时血压测量的形态没有任何显著影响。
