Littler W A, Honour A J, Carter R D, Sleight P
Br Med J. 1975 Aug 9;3(5979):346-8. doi: 10.1136/bmj.3.5979.346.
Direct arterial pressure was recorded continuously over 24 hours in 18 totally unrestricted people (six normotensives, four untreated hypertensives, and eight treated hypertensives). There was an almost equal fall of about 20% in both systolic and diastolic blood pressure during sleep in the three groups when compared with their waking pressures. This fall in pressure was greater than that observed previously in patients sleeping in a laboratory or hospital. Furthermore, it suggests that hypertensive subjects do not have a higher centrally-induced vasoactive component and that hypotensive drugs do not alter the pattern of blood pressure behaviour induced by sleep.
对18名完全不受限制的受试者（6名血压正常者、4名未经治疗的高血压患者和8名接受治疗的高血压患者）连续24小时记录动脉血压。与清醒时的血压相比，三组受试者在睡眠期间收缩压和舒张压均下降了近20%，降幅几乎相同。这种血压下降幅度大于先前在实验室或医院睡眠的患者中观察到的降幅。此外，这表明高血压受试者没有更高的中枢诱导血管活性成分，并且降压药物不会改变睡眠引起的血压变化模式。
