Cochrane A L, Moore F, Moncrieff C B
Br J Ind Med. 1982 Aug;39(3):265-8. doi: 10.1136/oem.39.3.265.
Coalminers with "A" shadows (the first stage of progressive massive fibrosis (PMF)) have a similar standardised mortality ratio (SMR) to those without PMF, and those with A shadows have a much higher specific mortality from pneumoconiosis. It is therefore argued that either A shadows confer immunity against some other disease(s) or that those developing A shadows are selected on the basis of increased life expectancy. These two hypotheses were investigated and as the selection hypothesis appeared promising further studies were made to discover which specific cause of death might be associated with this selection. This, surprisingly, appeared to be ischaemic heart disease.
患有“A”影(进行性大块纤维化(PMF)的第一阶段)的煤矿工人与没有PMF的工人具有相似的标准化死亡率(SMR),而有“A”影的工人因尘肺病导致的特定死亡率要高得多。因此有人认为,要么“A”影赋予了对某些其他疾病的免疫力,要么是那些出现“A”影的人是基于预期寿命的增加而被挑选出来的。对这两个假设进行了研究,由于选择假设看起来很有前景,因此进一步开展研究以发现哪种特定死因可能与这种选择有关。令人惊讶的是,这似乎是缺血性心脏病。