[单价阳离子对线粒体钙转运的影响]
[Effect of monovalent cations on calcium transport in the mitochondria].
作者信息
Orlov S N, Pokudin N I, Kravtsov G M
出版信息
Biull Eksp Biol Med. 1982 May;93(5):50-2.
Radioisotope exchange was used to study the effect of the Na+/K+ ratio on Ca2+ absorption and release from mitochondria of the rat myocardium, brain and fatty tissue. The increase in Na+ concentration in the incubation medium containing ATP and succinate leads to a 8-fold reduction of the Ca-accumulating capacity of brain mitochondria (K0,5 for Na+ 7 and 30 mM, respectively). A mechanism is suggested that explains the possibility of the Na-dependent regulation of the Ca-accumulating capacity of mitochondria of the tissues under consideration.
采用放射性同位素交换法研究了Na⁺/K⁺比值对大鼠心肌、脑和脂肪组织线粒体Ca²⁺吸收和释放的影响。在含有ATP和琥珀酸的孵育介质中，Na⁺浓度的增加导致脑线粒体Ca²⁺积累能力降低8倍（Na⁺的K0.5分别为7 mM和30 mM）。提出了一种机制，解释了所研究组织线粒体Ca²⁺积累能力的Na⁺依赖性调节的可能性。
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