Courjon J H, Flandrin J M, Jeannerod M, Schmid R
Brain Res. 1982 May 6;239(1):251-7. doi: 10.1016/0006-8993(82)90847-2.
Unilateral lesions of the cerebellar flocculus were made in two groups of cats chronically implanted for eye-movement recording. In the first group (3 cats), the floccular lesion preceded by 40-70 days a unilateral labyrinthectomy on the contralateral side. In the second group (5 cats), the serial order of the two lesions was reverted, the unilateral flocculectomy following unilateral labyrinthectomy by about 60 days in 2 animals and by 16-27 months in the other 3. The effects of the unilateral labyrinthectomy on the vestibulo-ocular reflex (spontaneous nystagmus and asymmetrical responses) were extensively tested by using natural vestibular stimulations. It was found that recovery from these effects was severely delayed in animals from the first group (flocculectomy prior to labyrinthectomy), although in animals from the second group the flocculectomy secondary to the labyrinthectomy only produced a transient asymmetry of vestibulo-ocular responses. It is concluded that the flocculus is required for initiating (not for maintaining), the compensatory process following peripheral lesions of the vestibular system.
在两组长期植入用于眼动记录的猫中制作了小脑绒球的单侧损伤。在第一组（3只猫）中，绒球损伤比同侧的单侧迷路切除术提前40 - 70天进行。在第二组（5只猫）中，两个损伤的顺序颠倒，在2只动物中单侧迷路切除术后约60天进行单侧绒球切除术，在另外3只动物中则在16 - 27个月后进行。通过使用自然前庭刺激，广泛测试了单侧迷路切除术对前庭眼反射（自发性眼球震颤和不对称反应）的影响。结果发现，第一组动物（迷路切除术之前进行绒球切除术）这些影响的恢复严重延迟，尽管在第二组动物中，迷路切除术后的绒球切除术仅产生了前庭眼反应的短暂不对称。结论是，前庭系统外周损伤后的代偿过程启动（而非维持）需要绒球。
