癌症患者对甲型和乙型流感灭活疫苗的血清抗体反应受损。
Impaired serum antibody response to inactivated influenza A and B vaccine in cancer patients.
作者信息
Stiver H G, Weinerman B H
出版信息
Can Med Assoc J. 1978 Oct 7;119(7):733,-5, 738.
Abstract
The serum antibody response to vaccination with bivalent inactivated influenza vaccine containing A/Port Chalmers/1/73 (H3N2) and B/Hong Kong/5/72 antigens was assessed in 44 patients with cancer and in 27 healthy control subjects. A fourfold or greater increase in antibody titre after vaccination occurred in 16 of the 44 cancer patients and 25 of the 27 controls for the A antigen, and in 14 of the 44 cancer patients and 20 of the 27 controls for the B antigen. Patients with lymphoma, who tended to have hypogammaglobulinemia, responded less well than did patients with solid tumours. Among the latter the failure to show a fourfold or greater increase in antibody titre correlated with a poorer 18-month survival.
摘要
在44例癌症患者和27名健康对照者中评估了针对含A/查尔姆斯港/1/73（H3N2）和B/香港/5/72抗原的二价灭活流感疫苗接种的血清抗体反应。接种疫苗后，44例癌症患者中有16例、27名对照者中有25例针对A抗原的抗体滴度升高四倍或更高；44例癌症患者中有14例、27名对照者中有20例针对B抗原的抗体滴度升高四倍或更高。倾向于有低丙种球蛋白血症的淋巴瘤患者的反应不如实体瘤患者。在实体瘤患者中，抗体滴度未能升高四倍或更高与18个月生存率较低相关。
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