O'Driscoll B R, Stevens F M, O'Gorman T A, Finnegan P, McWeeney J J, Little M P, Connolly C E, McCarthy C F
Gut. 1982 Aug;23(8):662-5. doi: 10.1136/gut.23.8.662.
HLA, A, B, and DR typing was done on seven of 10 patients with lymphoma, and six patients with carcinoma, all of whom had a flat small intestinal mucosa. Sixty-nine per cent (nine of 13) had HLA B8 and 71% (five of seven) had DR3. The corresponding levels for the local coeliac population are 76% and 84% respectively and the local non-coeliac population 43% and 44%. Two of the patients with lymphoma had a child with coeliac disease. The histological type of the lymphoma was malignant histiocytosis of the intestine in seven, histiocytic lymphoma in two, and was not classifiable in one. The similarity of the HLA type suggests that the flat mucosa in both groups is due to coeliac disease.
对10例淋巴瘤患者中的7例以及6例癌患者进行了HLA - A、B及DR分型,所有这些患者的小肠黏膜均呈扁平状。69%(13例中的9例)有HLA - B8,71%(7例中的5例)有DR3。当地乳糜泻人群的相应比例分别为76%和84%,当地非乳糜泻人群为43%和44%。2例淋巴瘤患者有患乳糜泻的孩子。淋巴瘤的组织学类型中,7例为肠道恶性组织细胞增多症,2例为组织细胞淋巴瘤,1例无法分类。HLA类型的相似性表明两组中的扁平黏膜均由乳糜泻所致。