Saarikoski S, Selander K, Kallio S, Pystynen P
Gynecol Obstet Invest. 1982;13(4):206-12. doi: 10.1159/000299519.
The presence of cytosol estrogen (ER) and progestin (PR) receptors in specimens of normal uterine cervix, endometrium, myometrium, Fallopian tubes and corpora lutei or in samples of neoplastic female reproductive tissues was investigated. The material consisted of PR and ER measurements of tissue samples obtained from fertile and postmenopausal women, receptor assays were performed by a dextran-coated charcoal technique. The radio PR/ER was highest in specimens from the Fallopian tubes (44) and endometrium (4-10),2-3 in specimens of uterine ecto- or endocervical epithelium and about 4 in the myometrium. No ER or PR were found in the four corpora lutei examined. PR or PR/ER ratio in specimens of myoma tissues did not differ from that found in the myometrium specimens. The highest ER and PR values in the endometrium were measured in specimens taken during the late proliferative or intermediate phase of the menstrual cycle. The PR values in specimens from postmenopausal myometrium were lower in comparison with the samples taken from the myometrium of fertile women in contrast to ER values. In the specimens of carcinoma of the vulva and the uterine cervix ER levels were very low, with no measureable values of PR. In the endometrial carcinoma samples the PR/ER ratio was lower than in the normal endometrium. 4 out of 7 specimens taken from ovarian adenocarcinoma had a measureable amount of ER and in 2 out of 7 cases PR.
研究了正常子宫颈、子宫内膜、子宫肌层、输卵管和黄体标本或女性生殖系统肿瘤组织样本中细胞溶质雌激素（ER）和孕激素（PR）受体的存在情况。材料包括对来自育龄和绝经后妇女的组织样本进行PR和ER测量，受体测定采用葡聚糖包被活性炭技术。输卵管（44）和子宫内膜（4 - 10）标本中的放射性PR/ER最高，子宫颈外或内上皮标本中为2 - 3，子宫肌层中约为4。在所检查的4个黄体中未发现ER或PR。肌瘤组织标本中的PR或PR/ER比值与子宫肌层标本中的无差异。子宫内膜中最高的ER和PR值在月经周期的增殖晚期或中间期采集的标本中测得。与ER值相反，绝经后子宫肌层标本中的PR值低于育龄妇女子宫肌层的样本。在外阴癌和子宫颈癌标本中，ER水平非常低，PR无可测量值。子宫内膜癌样本中的PR/ER比值低于正常子宫内膜。7例卵巢腺癌标本中有4例可检测到一定量的ER，7例中有2例可检测到PR。
