Hata T, Kita T, Itoh E, Namimatsu A
Nihon Yakurigaku Zasshi. 1982 Jun;79(6):487-92. doi: 10.1254/fpj.79.487.
Electrocardiography (ECG) was performed for SART stressed (repeated cold stressed) mice which had changes in blood pressure and blood flow to examine the effects of this treatment on heart function. In the ECG of mice subjected to SART stress for 5 days, potentiations of the R and T voltage, a shortening of the PQ interval, a prolongation of the QRS interval, and a slight increase of the heart rate were observed; and such changes in the ECG were maintained for several days. Recovery from all these changes was observed after a single dose or consecutive administration of propranolol. From these results, it is considered that sympathetic nerve activity may be increased in the function of the heart in SART stressed mice, as contrasted to the partial vagotonia in the duodenum. Neurotropin (NSP), a nerve sedative, was then administered to mice once daily for 5 days during the sart stress. NSP prevented the changes of the PQ and QRS interval in SART stressed mice, but could not prevent the potentiation of the R and T voltage and the heart rate increase. In particular, the potentiations of the R and T voltages were thought to be induced by the increase of sympathetic nerve activity; therefore, it is thought that NSP may not have direct actions at least on the sympathetic nerve sites in autonomic nervous systems.
对血压和血流发生变化的应激（反复冷应激）小鼠进行心电图（ECG）检查，以研究该处理对心脏功能的影响。在接受5天应激的小鼠心电图中，观察到R波和T波电压增强、PQ间期缩短、QRS间期延长以及心率略有增加；并且这些心电图变化持续了数天。在单次或连续给予普萘洛尔后，观察到所有这些变化均恢复。从这些结果来看，与十二指肠的部分迷走神经紧张相比，应激小鼠心脏功能中交感神经活动可能增强。然后在应激期间，每天给小鼠注射一次神经妥乐平（NSP），持续5天。NSP可防止应激小鼠PQ和QRS间期的变化，但不能防止R波和T波电压增强及心率增加。特别是，R波和T波电压增强被认为是由交感神经活动增加引起的；因此，认为NSP至少可能对自主神经系统中的交感神经部位没有直接作用。
