Popper H, Picher O, Auer H
Immunology. 1982 Jul;46(3):589-94.
An examination was made of the effects of eosinophilia on acute inflammation. Sprague Dawley rats were infected with Trichinella spiralis larvae which resulted in a blood eosinophilia. Groups of rats with the induced eosinophilia, and untreated rats without the eosinophilia, were treated with carrageenan, bradykinin or histamine in the hind paw to induce local inflammation. Paw oedema induced by carrageenan as a measure of the inflammation was much reduced in those rats with an eosinophilia, and slightly but significantly reduced in the site treated with histamine or bradykinin. Though other anti-inflammatory factors may have participated, it is believed that the reduction in inflammation was due to the eosinophils. Pretreatment of the rat paws with an eosinophil chemotactic factor tetrapeptide (ECF-A) caused no chemotaxis and therefore no effect on histamine-induced oedema.
对嗜酸性粒细胞增多症对急性炎症的影响进行了研究。将斯普拉格-道利大鼠感染旋毛虫幼虫，导致血液嗜酸性粒细胞增多。对诱导出嗜酸性粒细胞增多症的大鼠组和未诱导出嗜酸性粒细胞增多症的未处理大鼠，在后爪用角叉菜胶、缓激肽或组胺进行处理以诱导局部炎症。以角叉菜胶诱导的爪部水肿作为炎症的衡量指标，在嗜酸性粒细胞增多的大鼠中该水肿明显减轻，在用组胺或缓激肽处理的部位水肿略有但显著减轻。尽管可能有其他抗炎因子参与，但据信炎症减轻是由于嗜酸性粒细胞。用嗜酸性粒细胞趋化因子四肽（ECF-A）对大鼠爪子进行预处理未引起趋化作用，因此对组胺诱导的水肿没有影响。
