Pasternak J F, Groothuis D R, Fischer J M, Fischer D P
Neurology. 1983 May;33(5):559-66. doi: 10.1212/wnl.33.5.599.
The newborn beagle puppy serves as an animal model for intraventricular hemorrhage (IVH) of the premature infant. Since increased systemic blood pressure has been implicated in the genesis of IVH in both babies and puppies, we studied regional cerebral blood flow in control and hypertensive puppies. Hypertension significantly increased blood flow to all structures. The largest increases occurred in gray matter, especially deep cerebral and brainstem nuclei. Blood flow also increased to deep hemispheric white matter, but the magnitude of the increase was smaller. Hypertension also increased blood flow to the subependymal germinal matrix (GM). The magnitude of the increase to most of the GM was small and similar to deep hemispheric white matter. The increase to the most rostral GM was higher and equal to the mean increase seen in gray matter. This rostral-caudal gradient of hypertension-induced hyperperfusion may explain the tendency for IVH to occur in rostral GM in premature babies. However, the failure to find a disproportionate increase in blood flow to GM during hypertension implies that additional factors besides hypertension-induced GM hyperperfusion may be involved in the pathogenesis of IVH.
新生比格犬幼犬可作为早产儿脑室内出血（IVH）的动物模型。由于全身血压升高被认为与婴儿和幼犬IVH的发生有关，我们研究了对照幼犬和高血压幼犬的局部脑血流量。高血压显著增加了所有结构的血流量。最大的增加发生在灰质，尤其是大脑深部和脑干核团。半球深部白质的血流量也增加了，但增加幅度较小。高血压还增加了室管膜下生发基质（GM）的血流量。大多数GM区域的血流量增加幅度较小，与半球深部白质相似。最前端GM区域的血流量增加较高，与灰质中观察到的平均增加量相当。这种高血压诱导的高灌注的头尾梯度可能解释了早产儿IVH倾向于发生在前端GM区域的原因。然而，在高血压期间未发现GM血流量不成比例增加，这意味着除了高血压诱导的GM高灌注外，其他因素可能也参与了IVH的发病机制。
