Ment L R, Stewart W B, Scott D T, Duncan C C
Neurology. 1983 Feb;33(2):179-84. doi: 10.1212/wnl.33.2.179.
The newborn beagle puppy has been demonstrated to provide a good model for neonatal intraventricular hemorrhage (IVH). By randomized computerized design, indomethacin, a known inhibitor of prostaglandin synthetase, was administered to newborn beagle puppies, all of which underwent the experimental model of hemorrhagic hypotension followed by volume reexpansion for the production of IVH, to determine whether indomethacin can prevent intraventricular hemorrhage in this model. Nine percent of all pups receiving indomethacin experienced intraventricular hemorrhage, compared with 80% of animals who received the saline vehicle. In addition, significant alterations in the blood pressure responses to the hemorrhagic hypotension/volume reexpansion insult were noted in this group when compared with control animals.
新生比格犬已被证明是新生儿脑室内出血（IVH）的良好模型。通过随机计算机化设计，将已知的前列腺素合成酶抑制剂吲哚美辛给予新生比格犬，所有这些犬都接受了出血性低血压模型，随后进行容量再扩张以产生IVH，以确定吲哚美辛是否能预防该模型中的脑室内出血。接受吲哚美辛的所有幼犬中有9%发生了脑室内出血，而接受生理盐水载体的动物中这一比例为80%。此外，与对照动物相比，该组在出血性低血压/容量再扩张损伤后的血压反应有显著改变。
