Dill J R, Fox R A, Landrigan P L, MacSween J M, Osborn D C, Rajaraman R, Johsenhans W T
Clin Allergy. 1978 Jul;8(4):321-7. doi: 10.1111/j.1365-2222.1978.tb00467.x.
Leucocyte migration in the presence and absence of a soluble lung homogenate has been studied in a group of asymptomatic cigarette smokers. Results were expressed as migration indices. Controls consisted of age-matched subjects who had never smoked and had no past history of any pulmonary disease. The migration indices, the number of pack-years smoked and the results of pulmonary function studies were tested for correlation. The mean leucocyte migration index of the test group of sixteen smokers was significantly less than was that of the control group (P less than 0.001). Inhibition of leucocyte migration in the presence of the lung homogenate was not observed in any of the control subjects. Six of the sixteen asymptomatic cigarette smokers, however, were identified by inhibition of leucocyte migration in the presence of the lung homogenate. The number of pack-years which had been smoked did not correlate with the migration indices (r = -0.06); however, inhibition of leucocyte migration was not observed in subjects who had smoked less than 6 pack-years.
在一组无症状吸烟者中，研究了有无可溶性肺匀浆存在时白细胞的迁移情况。结果以迁移指数表示。对照组由年龄匹配、从不吸烟且无任何肺部疾病既往史的受试者组成。对迁移指数、吸烟包年数和肺功能研究结果进行相关性检验。16名吸烟者试验组的平均白细胞迁移指数显著低于对照组（P<0.001）。在任何对照组受试者中均未观察到在肺匀浆存在时白细胞迁移受到抑制。然而，16名无症状吸烟者中有6名在肺匀浆存在时白细胞迁移受到抑制。吸烟包年数与迁移指数无相关性（r = -0.06）；然而，吸烟少于6包年的受试者未观察到白细胞迁移受到抑制。
