Akishina R I, Voronkova V V, Pomortseva N V
Prikl Biokhim Mikrobiol. 1982 May-Jun;18(3):339-42.
The effect of the composition of the nutrient medium on the biosynthesis of biotin by the culture Actinomyces species 313-152 was investigated. This microorganism can synthesize biotin on simple and complex media. The biotin synthesis is stimulated by oleic acid and Tween-80 utilized by the culture as a carbon source. The exogenous biotin added at concentrations of 1 x 10(-8) M to 1 x 10(-6) M to the medium containing fodder yeast hydrolyzate and Tween-80 did not inhibit the synthesis by the culture Actinomyces species 313-152.
研究了营养培养基的组成对放线菌313 - 152菌株生物合成生物素的影响。这种微生物能在简单和复杂培养基上合成生物素。油酸和吐温80作为该菌株利用的碳源可刺激生物素的合成。向含有饲料酵母水解物和吐温80的培养基中添加浓度为1×10⁻⁸ M至1×10⁻⁶ M的外源生物素,并未抑制放线菌313 - 152菌株的合成。