Smith J A, Forward A D, Skidmore A G, Bell G A, Murphy J M
Surg Gynecol Obstet. 1982 Aug;155(2):235-7.
In an open study of 49 episodes of intra-abdominal sepsis in 48 patients, metronidazole was used in combination with tobramycin, and each was given by intravenous infusion. All patients were also treated by appropriate surgical operation. The ages of the patients ranged from 21 to 89 years, and both sexes were equally represented. Twenty-two patients had abscesses drained. Thirty-eight of 49 treatment courses gave good results. Eight patients recovered, although slowly, and three were classified as failures. Of the failures, one instance was attributed to infection with Staphylococcus aureus, and recovery was satisfactory when cloxacillin sodium was given. The other two failures were due, in part, to shock caused by trauma and blood loss in one instance and disseminated anaplastic lymphoma in the other. No significant adverse effects were attributable to the antibiotics.
在一项针对48例患者的49次腹腔内脓毒症发作的开放性研究中，甲硝唑与妥布霉素联合使用，均通过静脉输注给药。所有患者均接受了适当的外科手术治疗。患者年龄在21岁至89岁之间，男女比例均衡。22例患者的脓肿得到引流。49个治疗疗程中有38个取得了良好效果。8例患者虽恢复缓慢但最终康复，3例被判定为治疗失败。在治疗失败的病例中，1例归因于金黄色葡萄球菌感染，给予氯唑西林钠后恢复情况令人满意。另外2例治疗失败，其中1例部分原因是创伤和失血导致的休克，另1例是弥漫性间变性淋巴瘤。未发现抗生素有明显的不良反应。
