Khan M U
Trans R Soc Trop Med Hyg. 1982;76(2):164-8. doi: 10.1016/0035-9203(82)90266-8.
High attack rates, increasing resistance to antibiotics and high mortality make shigellosis a serious problem. As Shigella is associated with poor hygiene we examined the effectiveness of a simple intervention, washing hands with soap and water, in checking the spread of the disease. The study population was comprised of confirmed cases of shigellosis. These and matched controls were followed up for 10 days. Several pieces of soap and earthenware pitchers for storing water were provided to the study families and they were advised to wash their hands with soap and water after defaecation and before meals. Compliance was monitored daily by observing the size of the soap and residual water. Rectal swabs of contacts of both the groups were obtained for culture. The secondary infection rate was 10.1% in the study group and 32.4% in the control group. The secondary case (symptomatic) rate was 2.2% in the study group and 14.2% in the control group. These results suggest that hand-washing has a positive interrupting effect, even in unsanitary environments.
高发病率、对抗生素耐药性的增加以及高死亡率使志贺氏菌病成为一个严重问题。由于志贺氏菌与卫生条件差有关，我们研究了一种简单干预措施——用肥皂和水洗手——在控制该疾病传播方面的有效性。研究人群包括志贺氏菌病确诊病例。对这些病例及匹配的对照组进行了为期10天的随访。向研究家庭提供了几块肥皂和用于储水的陶罐，并建议他们在排便后和饭前用肥皂和水洗手。通过观察肥皂的大小和剩余水量每日监测依从性。采集两组接触者的直肠拭子进行培养。研究组的继发感染率为10.1%，对照组为32.4%。研究组的继发病例（有症状）率为2.2%，对照组为14.2%。这些结果表明，即使在不卫生的环境中，洗手也有积极的阻断作用。
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