Storey D M, Al-Mukhtar A S
Tropenmed Parasitol. 1982 Mar;33(1):23-4.
This study has shown tht exposure of jirds to radiation-attenuated larvae of one filarial species confers resistance to another species and thus indicates the potential for developing zooprophylactic regimens for the control of human filariasis. 13 and 8 Meriones unguiculatus were vaccinated with infective 3rd stage larvae of Litomosoides carinii attenuated by 40 krad Cobalt 60 irradiation and challenged with either L. carinii or Brugia pahangi respectively. Vaccinated jirds showed a 98% reduction in the expected challenge of L. carinii and a 71% reduction in the expected challenge of B. pahangi when compared to infectious in non-vaccinated controls.
本研究表明，将沙鼠暴露于一种丝虫物种的辐射减毒幼虫中可使其对另一种丝虫物种产生抗性，从而表明开发动物预防方案以控制人类丝虫病具有潜力。分别用经40千拉德钴60辐照减毒的卡氏住血丝虫感染性三期幼虫对13只和8只长爪沙鼠进行接种，并分别用卡氏住血丝虫或彭亨布鲁线虫进行攻击。与未接种的感染对照组相比，接种的沙鼠对卡氏住血丝虫的预期攻击减少了98%，对彭亨布鲁线虫的预期攻击减少了71%。
