Listopad G G, Chebotarev A N
Tsitol Genet. 1982 Mar-Apr;16(2):34-8.
The efficiency of SCE induction by six ethylene imine derivatives has been studied in the culture of human lymphocytes. It is found that there is a linear relation between SCE and a dose, irrespective of the number of functional groups and their distribution in the molecule. Hexamethyl triamid which has no functional ethylene imine groups does not induce SCE. The monocentric agents are more active than bicentric ones. A linear increase of SCE induced by a monofunctional agent does not agree with Shafer's bypass model.
已在人类淋巴细胞培养中研究了六种乙撑亚胺衍生物诱导姐妹染色单体交换（SCE）的效率。发现SCE与剂量之间存在线性关系，而与分子中官能团的数量及其分布无关。没有官能乙撑亚胺基团的六甲基三酰胺不诱导SCE。单中心试剂比双中心试剂更具活性。单官能试剂诱导的SCE线性增加与谢弗旁路模型不一致。
