Pinchuk V G, Livshits V L, Shuklinov V A, Tregubova N A
Tsitologiia. 1982 May;24(5):536-42.
A study of the fine structure of cells obtained from the transformed cloned culture of strain L, that have developed from a single cell, demonstrated several different cell types. The clones contained both non-differentiated and poorly-differentiated cells. The presence of morphotypical signs in the poorly-differentiated cells allowed to reveal some cell clone types and the direction of their specialization process. The study confirms the idea on the presence of the stem cell elements in the transformed cell culture of strain L causing the heterogenous way of cytodifferentiation and determining the long-term stability of cell polymorphism in this cell strain.
一项对从L株转化克隆培养物中获得的细胞精细结构的研究表明，这些细胞由单个细胞发育而来，呈现出几种不同的细胞类型。这些克隆包含未分化和低分化细胞。低分化细胞中形态学特征的存在有助于揭示一些细胞克隆类型及其分化过程的方向。该研究证实了L株转化细胞培养物中存在干细胞成分的观点，这些干细胞成分导致细胞分化的异质性方式，并决定了该细胞株中细胞多态性的长期稳定性。
