Dincsoy H P, Weesner R E, MacGee J
Am J Clin Pathol. 1982 Jul;78(1):35-41. doi: 10.1093/ajcp/78.1.35.
Forty-four cases of lipogranulomas (LG) in non-fatty livers (NFL), consisting of 38 biopsies and six autopsy livers, were studied. LG in NFL have a distinct morphologic characteristic and virtually all are attached to or closely associated with the walls of hepatic venules. The reason for this peculiar location remains unexplained. Our data from lipid histochemistry and analysis of lipid extracts from the livers and foodstuffs by thinlayer chromatography and gas-liquid chromatography indicate that LG in NFL most likely represent a reaction to absorbed saturated hydrocarbons, like mineral oil, used widely in the food industry. The incidence of LG is increasing, as evidenced by a 1.7% incidence in 1952-53 compared with 4.6% in 1978-80. LG seldom present a diagnostic problem provided serial sections are examined. An awareness of the characteristic morphology will prevent an extensive granuloma work-up. They appear to be an incidental finding in liver biopsies, and of no clinical significance at present; however, their long-term implication, if any, must await future observations.
对44例非脂肪肝（NFL）中的脂肪肉芽肿（LG）病例进行了研究，其中包括38例活检肝脏和6例尸检肝脏。NFL中的LG具有独特的形态学特征，几乎所有都附着于肝小静脉壁或与之紧密相关。这种特殊位置的原因尚不清楚。我们通过脂质组织化学以及利用薄层色谱法和气液色谱法对肝脏和食品中的脂质提取物进行分析的数据表明，NFL中的LG很可能是对吸收的饱和烃（如食品工业中广泛使用的矿物油）的一种反应。LG的发病率正在上升，1952 - 1953年的发病率为1.7%，而1978 - 1980年为4.6%。如果检查连续切片，LG很少会带来诊断难题。了解其特征性形态将避免对肉芽肿进行广泛检查。它们似乎是肝脏活检中的偶然发现，目前无临床意义；然而，其长期影响（如果有的话）必须等待未来的观察。
