口服阿昔洛韦在生殖器疱疹患者中的药代动力学。

Pharmacokinetics of orally administered acyclovir in patients with herpes progenitalis.

作者信息

Van Dyke R B, Connor J D, Wyborny C, Hintz M, Keeney R E

出版信息

Am J Med. 1982 Jul 20;73(1A):172-5. doi: 10.1016/0002-9343(82)90085-7.

Abstract

The pharmacokinetics of acyclovir administrated orally in a dose of 200 mg every four hours, five times a day to adults with herpes progenitalis was determined. Peak plasma acyclovir levels are found 1.5 to 1.75 hours after oral administration; peak levels range from 1.4 to 4.0 microM with a mean of 2.5 microM. Acyclovir levels in saliva are well correlated with simultaneous plasma levels, saliva levels being approximately 13 percent of plasma levels. Simultaneous plasma and vaginal secretion acyclovir levels are poorly correlated; peak levels in vaginal secretions range from 0.5 to 3.6 microM.

摘要

对患有生殖器疱疹的成年人，以每四小时200毫克、一天五次的剂量口服阿昔洛韦后的药代动力学进行了测定。口服给药后1.5至1.75小时可测得血浆阿昔洛韦水平峰值；峰值水平在1.4至4.0微摩尔之间，平均为2.5微摩尔。唾液中的阿昔洛韦水平与同时测得的血浆水平密切相关，唾液水平约为血浆水平的13%。血浆和阴道分泌物中阿昔洛韦的同步水平相关性较差；阴道分泌物中的峰值水平在0.5至3.6微摩尔之间。