酒精对充血性心力衰竭患者的急性影响。

Acute effects of alcohol in patients with congestive heart failure.

作者信息

Greenberg B H, Schutz R, Grunkemeier G L, Griswold H

出版信息

Ann Intern Med. 1982 Aug;97(2):171-5. doi: 10.7326/0003-4819-97-2-171.

Abstract

We evaluated the acute effects of moderate alcohol consumption in eight patients with New York Heart Association Functional Class III-IV congestive heart failure. Hemodynamic and echocardiographic variables were measured at baseline and then repeated at 30-minute intervals after ingestion of alcohol, 0.9 g/kg body weight, in the form of 80 proof vodka. Mean peak blood alcohol levels (+/- SE) at 60 minutes were 117 +/- 8 mg/dL. A significant reduction in mean arterial pressure, pulmonary artery and pulmonary artery wedge pressures, and systemic vascular resistance occurred over the first 90 minutes. Neither cardiac index, stroke volume index, stroke work index, nor echocardiographic variables were significantly changed. In patients with heart failure, a single moderate dose of alcohol reduces afterload by dilating arterial resistance vessels. No evidence of acute deterioration in cardiac performance was seen. In such patients occasional consumption of moderate dose alcohol can be safely tolerated.

摘要

我们评估了适度饮酒对8例纽约心脏协会心功能III - IV级充血性心力衰竭患者的急性影响。在基线时测量血流动力学和超声心动图变量，然后在摄入0.9 g/kg体重以80标准酒精度伏特加形式存在的酒精后，每隔30分钟重复测量一次。60分钟时的平均峰值血酒精水平（±标准误）为117±8 mg/dL。在最初的90分钟内，平均动脉压、肺动脉和肺动脉楔压以及全身血管阻力显著降低。心脏指数、每搏量指数、每搏功指数以及超声心动图变量均无显著变化。在心力衰竭患者中，单次适度剂量的酒精通过扩张动脉阻力血管降低后负荷。未观察到心脏功能急性恶化的证据。在此类患者中，偶尔摄入适度剂量的酒精可被安全耐受。